Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion. Emodin induces apoptosis of human cervical cancer cells through poly(ADP-ribose) polymerase cleavage and activation of caspase-9. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values of emodin were 32 and 64 μg/mL, respectively. Extract of Rhizoma Polygonum cuspidatum reduces early renal podocyte injury in streptozotocin‑induced diabetic rats and its active compound emodin inhibits methylglyoxal‑mediated glycation of proteins Authors: Eunjin Lin SP, Chu PM, Tsai SY, Wu MH, Hou YC. Il Polygonum cuspidatum (Fallopia japonica) è un pianta erbacea perenne, appartenente alla famiglia delle Polygonaceae. Mulholland, J. van Staden. Disease-Preventing Activities of Plant Products. Resveratrol and emodin Polygonum extract herb health benefit by Ray Sahelian, M.D. In vitro inhibitory effects of Polygonum cuspidatum on bacterial viability and virulence factors of Streptococcus mutans and Streptococcus sobrinus. POCU1b, the n-Butanol Soluble Fraction of Polygoni Cuspidati Rhizoma et Radix, Attenuates Obesity, Non-Alcoholic Fatty Liver, and Insulin Resistance via Inhibitions of Pancreatic Lipase, cAMP-Dependent PDE Activity, AMPK Activation, and SOCS-3 Suppression. P. cuspidatum Siebold & Zucc. Ganesh Jagetia, Sunil Krishnan Krishnan, Bharat B. Aggarwal. Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a chemical compound that can be isolated from rhubarb, buckthorn, and Japanese knotweed (Reynoutria japonica syn. Tatsuya Kaneshiro, Takamitsu Morioka, Morihiko Inamine, Tatsuya Kinjo, Junya Arakaki, Itaru Chiba, Nao Sunagawa, Masumi Suzui, Naoki Yoshimi. Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a chemical compound that can be isolated from rhubarb, buckthorn, and Japanese knotweed (Reynoutria japonica syn. Antonio R. da Cunha, Evandro L. Duarte, Hubert Stassen, M. Teresa Lamy, Kaline Coutinho. (PCS) has antibacterial properties and may prevent Ulcerative colitis (UC) but related molecular mechanism remains unknown. Jing Lu Liang, Hyo Chang Cha, Seung Ho Lee, Jong-Keun Son, Hyeun Wook Chang, Ji-Eun Eom, Youngjoo Kwon, Yurngdong Jahng. is a herbaceous perennial plant. Journal of the Korean Society of Food Science and Nutrition. Won-Kyung Yang, Yoon-Young Sung, Ho-Kyoung Kim. Synthesis of phenacyl derivatives of frangula-emodin and their HIV-1 RNase H activity. 5. FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors. Renal proximal tubular cell growth and differentiation are differentially modulated by renotropic growth factors and tyrosine kinase inhibitors. Z. M. Lang, H. L. Hong, L. M. Han, N. Zhu, Q. L. Suo. The Src Family Kinase Yes Triggers Hyperosmotic Activation of the Epidermal Growth Factor Receptor and CD95. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. Il Polygonum cuspidatum produce fusti sotterranei (rizomi) lunghi e robusti, capaci di svilupparsi in profondità. Guangsheng Qian, Sik-Yuen Leung, GuangHua Lu, Kelvin Sze-Yin Leung. Hitoshi NAGASHIMA, Kumiko NAKAMURA, Tetsuhisa GOTO. In the United States it is considered an invasive species as it is in most other countries. (A) Polygonum cuspidatum (PC), resveratrol, and emodin reduced plaque numbers in a plaque reduction assay. Supercritical CO2 extraction of emodin and physcion fromPolygonum cuspidatum and subsequent isolation by semipreparative chromatography. Acta Crystallographica Section D Structural Biology. La pianta è dotata di fusti vigorosi e glabri, che possono raggiungere un' altezza massima di 3-4 metri. Get article recommendations from ACS based on references in your Mendeley library. 細胞毒性 イタドリ emodin ↑ 6. Simple Flavones Possessing Complex Biological Activity. Lin SP, Chu PM, Tsai SY, Wu MH, Hou YC. Polygoni Cuspidati Radix Inhibits the Activation of Syk Kinase in Mast Cells for Antiallergic Activity. is rich with phenolics and has been used for the treatments of amenorrhea, arthralgia, jaundice, abscess, scald, and … 55, 696 (1992) Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells: A. Kumar, et al. First, it inhibits the motor activity of a parasitic Schistosoma species (Anantaphruti, et al, 1982). Hai Long Hong, Quan Ling Suo, Zhong Min Lang, Li Min Han, Chun Ping Li. Shailendra K. Saxena, Asif Elahi, Srinivasulu Gadugu, Anil K. Prasad. Polygonum cuspidatum Siebold & Zucc. Emodin (from Polygonum Cuspidatum Extract) inhibits the enzyme responsible for the conversion of cortisone into cortisol. The protein kinase 2 inhibitor tetrabromobenzotriazole protects against renal ischemia reperfusion injury. α-Synuclein Aggregation and Ser-129 Phosphorylation-dependent Cell Death in Oligodendroglial Cells. Salvador Máñez, María Del Carmen Recio. P. cuspidatum contains flavones, such as resveratrol and emodin as the major chemical constituents (27,28). You’ve supercharged your research process with ACS and Mendeley! Involvement of the Src family kinase yes in bile salt-induced apoptosis. Polygonum cuspidatum (PC), commonly called Japanese knotweed, is a member of the buckwheat family (Polygonaceae). The minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values of emodin were 32 and 64 μg/mL, respectively. Coombes, D.A. Qing Huang, Han-Ming Shen, Choon-Nam Ong. Stefania Sarno, Mauro Salvi, Roberto Battistutta, Giuseppe Zanotti, Lorenzo A. Pinna. Emodin, a Protein Tyrosine Kinase Inhibitor from Polygonum cuspidatum. Polygonum cuspidatum (PC), resveratrol, and emodin reduced plaque numbers in a plaque reduction assay and inhibited the accumulation of hemagglutinin and neuraminidase in A549 cells. Polygonum cuspidatum Siebold & Zucc. ; J. Nat. The Replacement of ATP by the Competitive Inhibitor Emodin Induces Conformational Modifications in the Catalytic Site of Protein Kinase CK2. Although used for various applications, few clinical studies validate claims and guidance regarding dosing or safety is limited. Inhibition. The common name is derived from Rheum emodi, a taxonomic synonym of Rheum australe, (Himalayan rhubarb) and synonyms include emodol, frangula emodin, rheum emodin, 3-methyl-1,6,8-trihydroxyanthraquinone, Schuttgelb, and Persian Berry Lake. Polygonum cuspidatumの地下茎の抽出物が含有するATP低下作用を持つ成 分の定。 2-3. emodinがin vitro、in vivoにおいてB16F10細胞の増殖に及ぼす影響。 2-4. emodinがミトコンドリアの機能に与える作 … Jongsung Lee, Eunsun Jung, Jiyoung Lee, Sungran Huh, Cheng-Hwan Hwang, Hwa-Young Lee, Eun-Jung Kim, Ji-Min Cheon, Chang Gu Hyun, Yeong Shik Kim, Deokhoon Park. M. Mizuno, H. Kawamura, N. Takei, H. Nawa. Possible anti-atherogenic effects of emodin, an anthraquinone from Chinese herbs and Aspergillus and Penicillium fungi.. F. Ernst, S. Hetzel, S. Stracke, D. Czock, G. Vargas, M. P. Lutz, F. Keller, P. M. Jehle. Feasibility Evaluation of Emodin (Rhubarb Extract) as an Inhibitor of Pancreatic Cancer Cell Proliferation In Vitro. Shahzad A. Pandith, Riyaz Ahmad Dar, Surrinder K. Lattoo, Manzoor A. Shah, Zafar A. Reshi. Evolution of Antimicrobial, Antioxidant Potentials and Phytochemical Studies of Three Solvent Extracts of Five Species from Acacia Used in Sudanese Ethnomedicine. Polygonum cuspidatum is used in traditional Chinese and Japanese medicine to treat a variety of diseases, including mold infections, various skin inflammations, cardiovascular diseases, and liver diseases. Investigation of the interactive effects between emodin and genistein in rat vascular smooth muscle cell line A-10. Emodin dose-dependently inhibited the level of melanin biosynthesis in B16 melanoma cells, with little cytotox- icity at the effective concentrations. Note: Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Ultrasonic-Assisted Extraction of the Botanical Dietary Supplement Resveratrol and Other Constituents of Polygonum cuspidatum. Journal of Separation Science 2006 , 29 (14) , 2136-2142. Polygonum cuspidatumの地下茎の抽出物が含有するATP低下作用を持つ成 分の定。 2-3. emodinがin vitro、in vivoにおいてB16F10細胞の増殖に及ぼす影響。 2-4. emodinがミトコンドリアの機能に与える作 … Pao-Hsuan Huang, Chih-Yang Huang, Mei-Chih Chen, Yueh-Tsung Lee, Chia-Herng Yue, Hsin-Yi Wang, Ho Lin. Constituents from Polygonum cuspidatum Kai X IAO , 1) Lijiang X UAN , Yaming X U ,* Donglu B AI , and Dexin Z HONG Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences; 294 P. cuspidatum also produces emodin, an anthraquinone, that has several effects. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Promotion of adiponectin multimerization by emodin: A novel AMPK activator with PPARγ‐agonist activity. 518-82-1 Chemical Name: 1,3,8-Trihydroxy-6-methylanthraquinone Other Extract origins: Rheum palmatum Rheum palmatum L roots Appearance: Orange needle crystal powder Specification: 10%~98% HPLC Molecular … J.C. Chukwujekwu, P.H. Derris laxiflora. Polygonum cuspidatum Yonggang Zhang, Airong Jia, Huabin Chen, Menghua Wang, Gang Ding, Liyan Sun, Li Li, Meixue Dai. Shih-Chang Chien, Yueh-Chen Wu, Zeng-Weng Chen, Wen-Chin Yang. Kun-Che Chang, Linfeng Li, Theresa M. Sanborn, Biehuoy Shieh, Patricia Lenhart, David Ammar, Daniel V. LaBarbera, and J. Eight active compounds have been identified from PC extract: 2-methoxystypandrone (1); emodin (2 Fangyuan Gao, Zihua Xu, Weizhong Wang, Guocai Lu, Yvan Vander Heyden, Tingting Zhou, Guorong Fan. Polygonum cuspidatum extract was administered orally, it had obvious inhibitory effects on mice with Ehrlich ascites carcinoma, sarcoma carcinoma 180, liver cancer, breast cancer, lymphosarcoma, melanoma, and Wacker carcinoma of rats. Volatile constituents from the leaves of Polygonum cuspidatum S. et Z. and their anti-bacterial activities. Yukihiro Imanishi, Naoto Maeda, Kohji Otogawa, Shuichi Seki, Hiroko Matsui, Norifumi Kawada, Tetsuo Arakawa. How to Polygonum Cuspidatum Extract Actions in pharmacological Composition analysis of Knotweed reveals it to be a vessel for resveratrol (as well as a few other compounds structurally similar to resveratrol and may act in the same way) and Rheum emodin .Both Free radical scavenging activity and antiproliferative potential of Polygonum cuspidatum root extracts. Emodin, an antibacterial anthraquinone from the roots of Cassia occidentalis. Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation. A comprehensive strategy using chromatographic profiles combined with chemometric methods: Application to quality control of Polygonum cuspidatum Sieb. 虎杖根(コジョウコン) Polygonum cuspidatum root 【基原】タデ科のイタドリの根茎。 【薬能・薬理作用】 アントラキノン・アントラキノン配糖体・フラボン配糖体・タンニン・多糖などを含む。がん抑制物質であるリスベラトロールを含む。 January 20 2016 Polygonum cuspidatum is an herb that has become popular since it is a rich source of resveratrol. 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