We report two cases of NPE and review the literature on NPE cases reported since 1990. Material and methods: The case of a 66-year-old male patient with NPE caused by repeated epileptic seizures is reported. Neurogenic pulmonary edema may be a complication of the terminal phase of cerebral tumors. Neurogenic pulmonary oedema as a rare complication of epileptic seizures Abstract Introduction: Neurogenic pulmonary oedema (NPE) is a very rare complication of epileptic seizures, which could potentially increase mortality. Neurogenic pulmonary edema is an etiological subtype of non-cardiogenic pulmonary edema, classified as a subtype of the acute respiratory distress syndrome by the Berlin definition.. Intracranial hypertension elic- Acute pulmonary edema following significant injury to the central nervous system is known as neurogenic pulmonary edema (NPE). Commonly seen after significant neurological trauma, NPE has also been described after seizure. Rapid resolution of pulmonary oedema is well documented by X-ray and computed tomography images. Neurogenic pulmonary edema develops within a few hours after a neurologic insult, and diagnosis requires exclusion of other causes of pulmonary edema (eg, high-altitude pulmonary edema). Neurogenic pulmonary edema (NPE) may be involved in seizure-related complications and SUDEP. Neurogenic pulmonary edema (NPE) is a relatively rare form of pulmonary edema caused by an increase in pulmonary interstitial and alveolar fluid. Neurogenic pulmonary edema is also an increasingly recognized complication of pediatric encephalitis with Enterovirus-71 (Hand, foot, and mouth disease) . The aim of this study is to explore the exact mechanism of epilepsy-induced NPE. The diagnosis 'tonic clonic seizure' is frequently established by emergency physicians on scene. In patients with epilepsy mortality due to accidents, asphyxia, cardiac arrhythmias or postictal neurogenic pulmonary oedema (NPO) is twice as high as in the general population. The ris ien intracranial pressure, i whics oftehn observed in conjunction with neurogenic pulmonary edema (Ducke anr d Simmons, 1968; Simmons et al., 1968), may be a requirement for th developmene t of pulmonary edema. • Signs of NPE in computed tomography (CT) examinations were retrospectively assessed in patients admitted for acute seizures. The diagnosis of neurogenic pulmonary edema is based on the occurrence of edema after a neurologic event/insult and the exclusion of other plausible causes. A 21-year-old man had a seizure episode following cranioplasty. The mechanism of neurogenic pulmonary edema in epilepsy ... sive seizure-related outpouring of central sympathetic activity, which leads to an increase in pulmonary vascular resistance [13, 14]. Epileptic seizures — Among all patients with epilepsy the occurrence of NPE is rare. Although several episodes of NPE resolve spontaneously, the condition may … • NPE was detected in 5 out of 47 patients • NPE has been documented in patients with cere-bral hemorrhage, subarachnoid hemorrhage, cerebral thrombosis, acute open and closed We report a case of acute pulmonary oedema after a tonic clonic seizure. drostatic pressure in the development of neurogenic pulmonary edema. Its pathophysiology is multifactorial but largely unknown. Neurogenic pulmonary edema (NPE) is characterized by the development of pulmonary edema within minutes to hours of a significant central nervous system (CNS) insult, often resolving spontaneously within 24–48 h [1,2,3].Febrile seizures (FS) is the most common convulsive event, affecting 2–5% of children younger than 60 months [4,5,6,7].The majority of FS cases follow a … While many pathogenic theories have been proposed, the exact mechanism remains unclear. 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