This new molecular histology of skin appendages is the foundation for forming new hypotheses on how molecules are mechanistically involved in skin appendage development and for designing experiments to test them. Skin appendages are derived from the skin and include hair, nails, and glands. The skin is the largest single organ of the body, typically accounting for 15%-20% of total body weight and, in adults, presenting 1.5-2 m 2 of surface to the external environment. 1 This maturation process is further outlined in Table 5-1. All of the components of skin contribute to this variation. Structure of the skin Skin varies markedly over different parts of the body. This may also lead to the modulation of healing and regeneration processes in future treatment modalities. Skin & Appendages Dr. Shahbaz Ahmad PT DPT[UIPT][UOL] MS-MSK-PT [UIPT][UOL]* Lecturer [LIHS][LCPS] 2. 42-43 in Histology for Pathologists, Sternberg, 1998; newer edition: Mills, Histology for Pathologists, 3rd ed., 2007). Most of the skin is haired although the hair in most areas is short, fine and only lightly pigmented. -General functions of the integumentary system are: Protection from mechanical injury. The skin appendages are epidermal and dermal derived components of the skin that include hair, nails, sweat glands, and sebaceous glands. Unit VII – Problem 8 – Histology: Skin & Appendages -The integumentary system consists of the skin and appendages which include: Sweat glands. Sebaceous glands. The main functions of the skin are protection (barrier against ultraviolet radiation, microorganisms, and water loss), the synthesis of vitamin D, detection of sensation (e.g., touch, temperature, pain), and the regulation of body temperature. This is actually not quite true. A maturing scar, however, does not fully recover its preinjury histology. This type of hair is called vellus hair. Consult a textbook for illustrations (e.g., pp. Each component has a unique structure, function, and histology. A characteristic feature of the human skin is the apparent lack of hair (pili) on most of the body surface. One of the best histology sites on the internet! There is complete loss of skin appendages, incomplete reformation of the rete ridges and papillary dermis, as well as alterations in the collagen fiber bundles. skin and appendages Histology 1. Appendages of the Skin Hair. A comprehensive, fun and entertaining site devoted exclusively to histology. Wheater’s Functional Histology Layers of Skin 1) Epidermis stratified squamous epithelium epidermal ridges 2) Dermis a) papillary layer small blood vessels, lymph & nerves fine collagen & elastic fibers b) reticular layer vascular plexus, lymph, nerves & appendages compact collagen fibers & thick elastic fibers 3) Hypodermis (subcutaneous) Nails. Start studying Histology Lippincott Chapter 8 (Skin and Epidermal Appendages). Each component has a unique structure, function, and histology. 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